Opioid Overdose Response and Prevention Resources

Discover how to effectively respond to opioid overdoses with our comprehensive resource guide. Learn essential overdose prevention techniques, the correct application of a naloxone, and become a vigilant guardian in your community.

1 person dies of overdose every 5 minutes

Provisional data from CDC’s National Center for Health Statistics indicate there were an estimated 107,543 drug overdose deaths in the United States during 2023.1,2

Research shows that bystanders are present in over a third of opioid overdoses and can prevent fatalities with the right resources.3

Bystanders are present in over a third of opioid overdoses and can prevent fatalities with the right resources.
Time with and without an opioid overdose rescue kit.

Access to opioid overdose emergency kits can reduce emergency response times by up to 75%, improving intervention effectiveness in critical situations.4

Opioid Treatment Program Directory

Search by state to find treatment programs that are accredited to treat opioid use disorders such as prescription pain medications and heroin.

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Overdose Signs

Signs and symptoms of opioid overdose.

Knowing what an opioid overdose looks like and how to treat it is essential. Administer naloxone and call 911 immediately if a person exhibits any of the above overdose signs.

Overdose Signs

Signs and symptoms of opioid overdose.

Knowing what an opioid overdose looks like and how to treat it is essential. Administer naloxone and call 911 immediately if a person exhibits any of the above overdose signs.

Key Support and Information for Opioid Overdose Prevention

  1. SAMHSA’s National Helpline: This helpline provides 24/7, free, and confidential treatment referral and information services for individuals and families facing mental and/or substance use disorders. Visit SAMHSA’s website.
  2. 988 Suicide & Crisis Lifeline: This resource offers 24/7 crisis support for those in distress, focusing on mental health crises and suicide prevention. Visit 988 Suicide & Crises Lifeline’s website.
  3. National Harm Reduction Coalition: This organization provides resources on harm reduction strategies, including overdose prevention, access to naloxone, and safer drug use practices. Visit National Harm Reduction Coalition’s website.
  4. DEA Recovery Resources: The DEA offers a comprehensive guide on recognizing the signs of addiction, finding treatment, and accessing recovery resources. Visit DEA Recovery Resources page.
  5. HHS Overdose Prevention Strategy: The U.S. Department of Health & Human Services provides various resources, including links to treatment facilities and educational materials about overdose prevention. Visit HHS’s website.

Latest News in Opioid Safety

A reminder that overdoses can happen anywhere — even in the middle of a championship celebration.
Every life matters, and each overdose is one too many. On July 11, we invite you to participate in a United Against Fentanyl Walk for Lives in your area where every step taken raises critical life-saving awareness, education, and resources in the fight against opioid overdose
In Oklahoma, Senate Bill 65 is now law, giving every person, school, business, and community organization in the state the legal right to possess and distribute life-saving naloxone.
While 2025 saw a promising 14% drop in overdose deaths, the drug supply is becoming more dangerous than ever, with newer substances already hitting the streets, some reported to be up to 10 times stronger than fentanyl.
A University of Oklahoma track and field champion turned HarborPath ambassador, Kennedy Clarke is channeling personal loss into action — getting naloxone and ODRescue products into the hands of students who need it most.
ODRescue™, a program dedicated to expanding on-demand access to life-saving products and sponsored by FFF Enterprises, Inc.— the nation’s most trusted specialty drug distributor and diversified healthcare company — today announced the launch of “Locate Naloxone Now.”
ABC 7 Amarillo spoke to Mia Hunter, executive director of the Community Awareness Rural Education (CARE) Team, about the importance of the ODRescue Box.
ODRescue™, a program of FFF Enterprises, Inc., announced the launch of ODRescue Alarm and ODRescue Alert. These on-demand emergency toolkits are designed for immediate, life-saving access to opioid overdose or anaphylaxis treatments with technological features to alert bystanders and nearby emergency personnel that help is needed.
On Sept. 20, 2025, FFF Enterprises and ODRescue™ teammates participated in the first Walk for Lives nationwide event presented by nonprofit United Against Fentanyl (UAF). Events in approximately 100 cities were organized by families affected by fentanyl overdoses. Each walk sought to raise awareness, provide education and resources, and create partnerships within communities to help save lives.

Understanding Naloxone

According to the Centers for Disease Control and Prevention (CDC), naloxone is a medicine that can help people who are overdosing on an opioid. Naloxone, the active ingredient in opioid reversal agents, competes with opioids to bind with the same receptors in the brain, reversing the effects of an opioid overdose in as little as 2 to 3 minutes.

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References

  1. U.S. Overdose Deaths Decrease in 2023, First Time Since 2018
    https://www.cdc.gov/nchs/pressroom/releases/20240515.html
    Accessed July 2024
  2. U.S. Overdose Deaths In 2021 Increased Half as Much as in 2020 – But Are Still Up 15%
    https://www.cdc.gov/nchs/pressroom/releases/20220511.html
    Accessed July 2024
  3. Vital Signs: Characteristics of Drug Overdose Deaths Involving Opioids and Stimulants — 24 States and the District of Columbia, January–June 2019
    www.cdc.gov/mmwr/volumes/69/wr/mm6935a1.htm
    Accessed July 2024
  4. The Effect of Overdose Education and Naloxone Distribution: An Umbrella Review of Systematic Reviews
    ajph.aphapublications.org/doi/epub/10.2105/AJPH.2021.306306
    Accessed July 2024